A study of topological characteristics in pattern perception physiology in the mammalian cortex

Experimental procedures for studying topological characteristics in pattern perception physiology of rat cerebral corte

Rethinking one`s own culture

African people reflecting on their own situation will frequently find themselves in a dilemma to identify with western and traditional values. A case study of the Burji (Ethiopia and Kenya) examplifies this. First a description is given of the Burji actively dealing with their problems, trying among other things to keep Burjiness alive. Then in presenting a semiotic model it is shown how the phenomenon of their changing group identity (which is not grasped by theories of ethnic group or ethnicity) can be analyzed. The model presented may be useful for analyzing similar cases in the Third World

Corrigendum to "Coupling the SO(2) supergravity through dimensional reduction" [Phys. Lett. B 96 (1-2) (1980) 89-93]

Due to renewed interest in D=5 supergravity and its quartic fermionic terms, fuelled by very recent work on supersymmetric quantum cosmology we correct an error in eq.(4) of the paper cited in the title. We also give the Lagrangian in second order formalism which was not explicitly written out before.Comment: Erratum, 2 pages, Phys. Lett. B in Pres

The role of organic polymers in the structure of cometary dust

Several phenomena observed in P/Halley and other comets indicate additional fragmentation of dust particles or dust aggregates in cometary atmospheres. The disintegration of dust aggregates may be explained by sublimation of polymerized formaldehyde - POM - which play a role as binding material between submicron individual particles

Laboratory studies on cometary crust formation: The importance of sintering

It is demonstrated by experiments and theoretical considerations that sintering processes, so far used to describe the densification of metal and ceramic powders, are relevant for icy materials and therefore probably also for comets. A theoretical model is presented which describes the evolution of so called sinter necks, the contact zone between ice particles. With this model the strength increase of a porous, loosley packed icy body is calculated in which the sinter necks grow by evaporation and condensation of water vapor at a constant temperature. Experiments with ice powders validate the model qualitatively. An increase in strength up to a factor of four is observed during isothermal sintering. In order to check the relevance of the experimental results and the basic theoretical ideas with respect to real comets, more exact theories and improved experiments taking into account additional mass transport mechanisms are needed

Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas

Platinum drug-resistance in ovarian cancers is a major factor contributing to chemotherapeutic resistance of recurrent disease. Members of the Bcl-2 family such as the anti-apoptotic protein Bcl-XL have been shown to play a role in this resistance. Consequently, concurrent inhibition of Bcl-XL in combination with standard chemotherapy may improve treatment outcomes for ovarian cancer patients. Here, we develop a mathematical model to investigate the potential of combination therapy with ABT-737, a small molecule inhibitor of Bcl-XL, and carboplatin, a platinum-based drug, on a simulated tumor xenograft. The model is calibrated against in vivo\ud experimental data, wherein tumor xenografts were established in mice and treated with ABT-737 and carboplatin on a fixed periodic schedule, alone or in combination, and tumor sizes recorded regularly. We show that the validated model can be used to predict the minimum drug load that will achieve a predetermined level of tumor growth inhibition, thereby maximizing the synergy between the two drugs. Our simulations suggest that the time of infusion of each carboplatin dose is a critical parameter, with an 8-hour infusion of carboplatin administered each week combined with a daily bolus dose of ABT-737 predicted to minimize residual disease. We also investigate the potential of ABT-737 co-therapy with carboplatin to prevent or delay the onset of carboplatin-resistance under two scenarios. When resistance is acquired as a result of aberrant DNA-damage repair in cells treated with carboplatin, the model is used to identify drug delivery schedules that induce tumor remission with even low doses of combination therapy. When resistance is intrinsic, due to a pre-existing cohort of resistant cells, tumor remission is no longer feasible, but our model can be used to identify dosing strategies that extend disease-free survival periods. These results underscore the potential of our model to accelerate the development of novel therapeutics such as ABT-737, by predicting optimal treatment strategies when these drugs are given in combination with currently approved cancer medications

The Reliance : March And Two - Step

https://digitalcommons.library.umaine.edu/mmb-ps/2363/thumbnail.jp